120 13.5 Disorders of the Respiratory System

Created by CK-12 Foundation/Adapted by Christine Miller

13.5.1 Dust Mite
Figure 13.5.1 This is “mitey” scary looking.

A “Mitey” Monster

The scary beast in Figure 13.5.1 is likely to be lurking in your own home, where it feeds on organic debris, including human skin. What is it? It’s the common dust mite, a close relative of spiders. The dust mite is so small that it is barely visible with the unaided eye, so it’s obviously shown greatly enlarged above. If you think you can get rid of dust mites in your home by frequent and thorough cleaning, think again. There may be thousands of dust mites in just one gram of dust! Regardless of how clean you keep your house, you can’t eliminate dust mites entirely. So why even bother trying? The feces of dust mites contain proteins that are a common trigger of asthma attacks.

Asthma

 

13.5.2 Asthma
Figure 13.5.2 During an asthma attack, airways narrow and may become clogged with mucus, making breathing difficult.

is a chronic inflammatory disease of the airways in the lungs, in which the airways periodically become inflamed. As you can see in Figure 13.5.2, this causes swelling and narrowing of the airways, often accompanied by excessive mucus production. Symptoms of asthma include difficulty breathing, coughing, wheezing, shortness of breath, and chest tightness. Some people with asthma rarely experience symptoms, and then usually only in response to certain triggers in the environment. Other people may have symptoms almost all of the time.

Asthma is thought to be caused by a combination of genetic and environmental factors. A person with a family history of asthma is more likely to develop the disease. Dozens of genes have been found to be associated with asthma, many of which are related to the immune system. Additional risk factors include obesity and sleep apnea. Environmental factors trigger asthma attacks in people who have a genetic predisposition to the disease. Besides dust mite feces, triggers may include other allergens (such as pet dander, cockroaches, and mold), certain medications including aspirin, air pollution, and stress. Symptoms tend to be worse at night and early in the morning. They may also worsen during upper respiratory tract infections, strenuous exercise, or when the airways are exposed to cold air.

13.5.3 Asthma Inhaler
Figure 13.5.3 Use of inhaled bronchodilators (medications which cause the bronchi to expand) can help patients manage the long-term effects of living with asthma.

There is no cure for asthma at present, but the symptoms of asthma attacks usually can be reversed with the use of inhaled medications called bronchodilators (as shown in Figure 13.5.3). These medications soothe the constricted air passages and help to re-expand them, making breathing easier. The medications usually start to take effect almost immediately. Other medications can be taken for long-term control of the disease. These medications help prevent asthma attacks from occurring. Corticosteroids are generally considered the most effective treatment for long-term control. Another way to prevent asthma attacks is by avoiding triggers whenever possible.

Pneumonia

Another common inflammatory disease of the respiratory tract is . In pneumonia, inflammation affects primarily the , which are the tiny air sacs of the lungs. Inflammation causes some of the alveoli to become filled with fluid so that gas exchange cannot occur, as you can see illustrated in Figure 13.5.4. Symptoms of pneumonia typically include coughing, chest pain, difficulty breathing, and fever.

13.5.4 Pneumonia
Figure 13.5.4 Fluid-filled alveoli characteristic of pneumonia inhibit normal gas exchange with the blood.

Pneumonia often develops as a consequence of an infection (such as the common cold or flu), especially in the very young and the elderly. It is usually caused by  or , although some cases may be caused by other microorganisms, such as fungi. The majority of cases are caused by just a few pathogens, the most common being the bacterium Streptococcus pneumoniae. Pneumonia is more likely to develop in people who have other lung diseases, such as , a history of smoking, heart failure, or a weakened immune system.

 are available to prevent certain types of bacterial and viral pneumonia, including pneumonia caused by Streptococcus pneumoniae. Treatment of pneumonia depends on the cause. For example, if the disease is caused by bacteria, antibiotics are generally prescribed. In cases of severe pneumonia, hospitalization and supplemental oxygen may be required.

Chronic Obstructive Pulmonary Disease

(COPD) is a lung disease characterized by chronic poor airflow due to increasing in-elasticity of lung tissue and breakdown of the walls of the alveoli. The main symptoms include shortness of breath and a cough that produces phlegm. These symptoms are usually present for a long period of time, and typically become worse over time. Eventually, walking up stairs and similar activities become difficult because of shortness of breath.

COPD formerly was referred to as chronic bronchitis or emphysema. Now, the term chronic bronchitis is used to refer to the symptoms of COPD, and the term emphysema is used to refer to the lung changes that occur with COPD. Some of these lung changes are shown in Figure 13.5.5 below. They include a breakdown of connective tissues that reduces the number and elasticity of alveoli. As a result, the patient can no longer fully exhale air from the lungs, so air becomes trapped in the lungs. Gas exchange is hampered and may lead to low oxygen levels, as well as too much carbon dioxide in the blood.

13.5.5 COPD
Figure 13.5.5 The physiological changes that occur with COPD include a breakdown of alveolar walls, reducing the surface area for gas exchange.

Smoking tobacco and vaping are the major cause of COPD, with a number of other factors such as air pollution and genetics playing smaller roles. Of people who are life-long smokers, about half will eventually develop COPD. Exposure to secondhand smoke in nonsmokers also increases the risk of COPD, and accounts for about 20 per cent of cases.  Most cases of COPD could have been prevented by never smoking or vaping. In people who have already been diagnosed with COPD, cessation of smoking or vaping can slow down the rate at which COPD worsens. People with COPD may be treated with supplemental oxygen and inhaled bronchodilators. These treatments may reduce the symptoms, but there is no cure for COPD except — in very severe cases — lung transplantation.

Lung Cancer

 is a malignant tumor characterized by uncontrolled cell growth in tissues of the lung. The tumor may arise directly from lung tissue (primary lung cancer), or as a result of from cancer in another part of the body (secondary lung cancer). Primary lung cancer may also metastasize and spread to other parts of the body. Lung cancer develops after genetic damage to  that affects the normal functions of the cell. As more damage accumulates, the risk of cancer increases. The most common symptoms of lung cancer include coughing (especially coughing up blood), wheezing, shortness of breath, chest pain, and weight loss.

The major cause of primary lung cancer is tobacco use, which accounts for about 85 per cent of cases. Cigarette smoke contains numerous cancer-causing chemicals. Besides smoking, other potential causes of lung cancer include exposure to radon gas, asbestos, secondhand smoke, or other air pollutants. When tobacco smoking is combined with another risk factor (such as exposure to radon or asbestos), the risk of lung cancer is heightened. People who have close biological relatives with lung cancer are also at increased risk of developing the disease.

Most cases of lung cancer cannot be cured. In many people, the cancer has already spread beyond the original site by the time they have symptoms and seek medical attention. About ten per cent of people with lung cancer do not have symptoms when they are diagnosed, and the cancers are found when they have a chest X-ray for another problem. In part because of its typically late diagnosis, lung cancer is the most common cause of cancer-related death in men, and the second most common cause in women (after breast cancer). Approximately 21,000 Canadians die from lung cancer each year.  Common treatments for lung cancer include surgical removal of the tumor, radiation therapy, chemotherapy, or some combination of these three types of treatment.

Feature: My Human Body

Do you — or someone you love — snore? Snoring may be more than just an annoyance. It may also be a sign of a potentially dangerous and common disorder known as sleep apnea.  is characterized by pauses in breathing that occur most often because of physical blockage to airflow during sleep. When breathing is paused, carbon dioxide builds up in the bloodstream. The higher-than-normal level of carbon dioxide in the blood causes the respiratory centers in the brain to wake the person enough to start breathing normally. This reduces the carbon dioxide level, and the person falls back asleep. This occurs repeatedly throughout the night, causing serious disruption in sleep. Most people with sleep apnea are unaware that they have the disorder, because they don’t wake up fully enough to remember the repeated awakenings throughout the night. Instead, sleep apnea is more commonly recognized by other people who witness the episodes.

Figure 13.5.6 below shows how sleep apnea typically occurs. The muscle tone of the body normally relaxes during sleep, allowing the soft tissues in the throat to collapse and block the airway. The relaxation of muscles may be exacerbated by the use of alcohol, tranquilizers, or muscle relaxants. The risk of sleep apnea is greater in people who are overweight, smoke tobacco, or have diabetes. The disorder is also more likely to occur in older people and males. Common symptoms of sleep apnea include loud snoring, restless sleep, and daytime sleepiness and fatigue. Daytime sleepiness, in turn, increases the risk of driving and work-related accidents. Continued sleep deprivation may cause moodiness and belligerence. Lack of adequate oxygen to the body because of sleep apnea may also lead to other health problems, including fatty liver diseases and high blood pressure. Symptoms of sleep apnea may be present for years — or even decades — until (and if) a diagnosis is finally made.

15.5.6 Sleep Apnea Airway Blockage
Figure 13.5.6 Sleeping on one’s back may increase the risk of the airway becoming temporarily blocked during sleep, resulting in sleep apnea.
15.5.7 CPAP to Treat Sleep Apnea
Figure 13.5.7 The use of a CPAP machine can be used to treat sleep apnea.

Treatment of sleep apnea may include avoiding alcohol, quitting smoking, or losing weight. Elevating the upper body during sleep or sleeping on one’s side may help prevent airway collapse in many people with sleep apnea. Another type of treatment is the use of an oral device that shifts the lower jaw forward to help keep the airway open during sleep. The most common treatment for moderate to severe sleep apnea is the use of CPAP (constant positive air pressure), which keeps the airway open by means of pressurized air during sleep. In this treatment, the person typically wears a plastic facial mask that is connected by a flexible tube to a small bedside CPAP machine as shown to the right in Figure 13.5.7. Although CPAP is effective, long-term compliance is often poor, because patients find the mask uncomfortable or they experience unpleasant side effects, such as dry mouth and nose. A more extreme form of treatment is surgery to remove some of the tissues — such as the tonsils or part of the soft palate — that tend to collapse and block the airway in people with sleep apnea.

13.5 Summary

  • is a chronic inflammatory disease of the airways in the lungs, in which the airways periodically become inflamed. This causes swelling and narrowing of the airways, often with excessive mucus production, leading to difficulty breathing and other symptoms. Asthma is thought to be caused by a combination of genetic and environmental factors. Asthma attacks are triggered by allergens, air pollution, or other factors.
  • is a common inflammatory disease of the respiratory tract, in which inflammation affects primarily the alveoli, which become filled with fluid that inhibits gas exchange. Most cases of pneumonia are caused by viral or bacterial infections. Vaccines are available to prevent pneumonia. Treatment often includes prescription antibiotics.
  • (COPD) is a lung disease characterized by chronic poor airflow, which causes shortness of breath and a productive cough. It is caused most often by tobacco smoking, which leads to breakdown of connective tissues in the lungs. Alveoli are reduced in number and elasticity, making it impossible to fully exhale air from the lungs. There is no cure for COPD, but stopping smoking may reduce the rate at which COPD worsens.
  • is a malignant tumor characterized by uncontrolled cell growth in tissues of the lung. It results from accumulated DNA damage, most often caused by tobacco smoking. Lung cancer is typically diagnosed late, so most cases cannot be cured. It may be treated with surgery, chemotherapy, and/or radiation therapy.

13.5 Review Questions

  1. How can asthma attacks be prevented? How can symptoms of asthma attacks be controlled?.
  2. How can pneumonia be prevented? How is it treated?
  3. What is the difference between primary and secondary lung cancer? What is the major cause of primary lung cancer? Discuss lung cancer as a cause of death. How is lung cancer treated?
  4. What is the difference between how COPD and pneumonia affect the alveoli?

13.5 Explore More

Shaf Keshavjee at TEDMED 2010.

Immunology of the Lung, Nature Video, 2014.

What you should know about vaping and e-cigarettes, TEDMED, 2019.

What your breath could reveal about your health | Julian Burschka, TED, 2019.

 

Attributions

Figure 13.5.1

House_Dust_Mite by Employee of US Food and Drug Administration (archived) on Wikimedia Commons is in the public domain (https://en.wikipedia.org/wiki/Public_domain).

Figure 13.5.2

Asthma_attack-illustration_NIH by National Heart, Lung, Blood Institute/ U.S. National Institute of Health on Wikimedia Commons is in the public domain (https://en.wikipedia.org/wiki/Public_domain).

Figure 13.5.3

asthma-inhaler by Anthony Poynton on Public Domain Pictures is used under a CC0 1.0  Universal Public Domain Dedication License (https://creativecommons.org/publicdomain/zero/1.0/).

Figure 13.5.4

Lobar_pneumonia_illustrated by National Heart, Lung and Blood Institute / U.S. National Institute of Health on Wikimedia Commons is in the public domain (https://en.wikipedia.org/wiki/Public_domain).

Figure 13.5.5

Blausen_0343_Emphysema by Blausen Medical Communications, Inc. on Wikimedia Commons is used under a CC BY 3.0 (https://creativecommons.org/licenses/by/3.0) license.

Figure 13.5.6

Airway_obstruction by Drcamachoent on Wikimedia Commons is used under a CC BY-SA 4.0 (https://creativecommons.org/licenses/by-sa/4.0) license.

Figure 13.5.7

Depiction_of_a_Sleep_Apnea_patient_using_a_CPAP_machine by https://www.myupchar.com/en on Wikimedia Commons is used under a CC BY-SA 4.0 (https://creativecommons.org/licenses/by-sa/4.0) license.

References

Centers for Disease Control and Prevention (CDC). (2020). Travel: Pneumococcal disease (streptococcus pneumoniae) [online article]. U.S. Department of Health & Human Services. https://wwwnc.cdc.gov/travel/diseases/pneumococcal-disease-streptococcus-pneumoniae

Nature Video. (2014, December 15). Immunology of the lung. YouTube. https://www.youtube.com/watch?v=rgphaHmAC_A&feature=youtu.be

TED. (2019, February 25). What your breath could reveal about your health | Julian Burschka. YouTube. https://www.youtube.com/watch?v=aQsOmGflf1o&feature=youtu.be

TEDMED. (2010, December 7). Shaf Keshavjee at TEDMED 2010. YouTube. https://www.youtube.com/watch?v=T2EmuyHoMAI&feature=youtu.be

TEDMED. (2019, May 15). What you should know about vaping and e-cigarettes. YouTube. https://www.youtube.com/watch?v=W1rF2oFnfYI&feature=youtu.be

License

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Human Biology by Christine Miller is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, except where otherwise noted.

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